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DEMETHYL EPIPODOPHYLLOTOXIN ETHYLIDINE GLUCOSIDE
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DeCS
Descriptor
English
:
Etoposide
Descriptor
Spanish
:
Etopósido
Descriptor
Portuguese
:
Etoposídeo
Synonyms
English
:
Demethyl Epipodophyllotoxin Ethylidine Glucoside
Tree Number:
D02.455.426.559.847.638.960.675.250
D04.615.638.960.675.250
D09.408.348.275
Definition
English
:
A semisynthetic derivative of
PODOPHYLLOTOXIN
that exhibits antitumor activity.
Etoposide
inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of
cell division
, and lead to
cell death
.
Etoposide
acts primarily in the G2 and S phases of the
cell cycle.
Pharmacological Action:
Antineoplastic Agents, Phytogenic
Topoisomerase II Inhibitors
History Note
English
:
87(81); was see under PODOPHYLLOTOXIN 1981-86; was VP 16-213 see under PODOPHYLLOTOXIN 1976-80
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
5143
Unique Identifier:
D005047
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS